動態負重測試

動態負重測試

品名:DYNAMIC WEIGHT BEARING

廠牌:

動態負重測試為基於影片來評估動物肢體動作的高端儀器,可利用動態條件下最先進的形態學分析算法,實現更快的四肢識別。在評估涉及大鼠和小鼠的鎮痛/傷害感受的研究中的疼痛敏感性時,可以替代傳統的權運動功能喪失來評估疼痛敏感性,這是一種有效且先進的方法,其中包括骨關節炎,骨癌,鎮痛藥,帕金森氏症,異常性疼痛的研究…

Bioseb的DBW可讓被測動物(大鼠或小鼠)在透明籠子中自由移動的。這種獨特的特性大大降低了約束產生的失準情形,因此大大提高了結果的可靠性。

 

可得參數:

  • Weight for each paw (g and % total animal weight)
  • Weight for grouped front and rear paws (g and %total animal weight)
  • Left/Right and Front/Rear weight ratio
  • Surface for each paw (mm²)
  • Surface for grouped front and rear paws (mm²)
  • Variability (standart deviation/mean) for each parameter
  • Parameters are given for each posture and as a mean for the whole experiment
  • Duration of different postures (4 paws, rearing…) over the whole experiment (s)
  • Total time spent on each paw over the whole experiment (s)

參考文獻:

• Apamin from bee venom suppresses inflammation in a murine model of gouty arthritis (2020)
• Intra-articular AAV-PHP. S mediated chemogenetic targeting of knee-innervating DRG neurons alleviates inflammatory pain in mice (2020)
• Total Knee Arthroplasty with a Ti6Al4V/PEEK Prosthesis on an Osteoarthritis Rat Model: Behavioral and Neurophysiological Analysis (2020)
• Pain and knee damage in male and female mice in the medial meniscal transection-induced osteoarthritis Pain and knee damage in male and female mice in the medial meniscal transection-induced osteoarthritis (2019)
• Intra-articular treatment with triamcinolone acetonide-loaded liposomes in the rat high-fat diet groove model (2019)
• Intra-articular injection of triamcinolone acetonide releasing biomaterial microspheres inhibits pain and inflammation in an acute arthritis model (2019)
• Applicability of a Modi_ed Rat Model of Acute Arthritis for Long-Term Testing of Drug Delivery Systems (2019)
• The analgesic effect of intraarticular OnabotulinumtoxinA in a female murine model of collagenase induced chronic degenerative monoarthritis (2018)
• Microglial pannexin-1 channel activation is a spinal determinant of joint pain (2018)
• Investigation of Lake HŽv’z Mineral Water Balneotherapy and HŽv’z Mud Treatment in Murine Osteoarthritis and Rheumatoid Arthritis Models (2018)
• Modulation of the NGF–TRKA pathway for treatment of joint pain: preclinical in vivo evaluation in mice (2018)
• Evaluation of the novel avocado/soybean unsaponifiable Arthrocen to alter joint pain and inflammation in a rat model of osteoarthritis (2018)
• Oral administration of undenatured native chicken type II collagen (UC-II) diminished deterioration of articular cartilage in a rat model of osteoarthritis (OA) (2017)
• Effects of Mollugo pentaphylla extract on monosodium urate crystal-induced gouty arthritis in mice (2017)
• Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology (2015)
• Dynamic weight bearing is an efficient and predictable method for evaluation of arthritic nociception and its pathophysiological mechanisms in mice (2015)
• Correlation between ?CT imaging, histology and functional capacity of the osteoarthritic knee in the rat model of osteoarthritis (2015)
• The Effects of Endocannabinoid Modulation and Neurogenic Inflammation in Experimental Knee Joint Arthritis (2015)
• A multi-target approach for pain treatment: dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis (2015)
• Neuroplasticity of sensory and sympathetic nerve fibers in the painful arthritic joint. (2012)
• Articular Mesenchymal Stem Cell (MSC) and Effects of Growth Differentiation Factor-5 (GDF-5). (2010)